Combined Transcriptional and Translational Targeting of EWS/FLI-1 in Ewing's Sarcoma
نویسندگان
چکیده
منابع مشابه
Combined transcriptional and translational targeting of EWS/FLI-1 in Ewing's sarcoma.
PURPOSE To show the efficacy of targeting EWS/FLI-1 expression with a combination of specific antisense oligonucleotides and rapamycin for the control of Ewing's sarcoma (EWS) cell proliferation in vitro and the treatment of mouse tumor xenografts in vivo. EXPERIMENTAL DESIGN EWS cells were simultaneously exposed to EWS/FLI-1-specific antisense oligonucleotides and rapamycin for various time ...
متن کاملPrimary Extraskeletal Ewings Sarcoma of Ala of Nose . 1
Extra skeletal Ewing's sarcoma is often described as a tumour involving the soft tissues of the lower extremities and the para vertebral region. Ewing's sarcoma presents a rare tumour of the head and neck, and even rarer in the nasal cavity and/or paranasal sinuses. Primary Ewing’s sarcoma of the ala of the nose has not been commonly described previously in the English literature. We present a ...
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BACKGROUND Extraskeletal Ewings sarcoma are rare tumors for which there is no consensus on optimal management. METHODS A retrospective review of the clinical features, treatment and outcome of patients with extraskeletal Ewings sarcoma who reported to a single institution between January 1992-December 2003 is reported. RESULTS A total of 19 patients with extraskeletal Ewings sarcoma were id...
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Primary malignant sarcomas of the spine are extremely rare. Because of biological heterogeneity, these tumors have variable sensitivity to radiation and chemotherapy. Adequate local control through complete tumor removal is an important therapeutic goal. However, aggressive resection of tumors in the spinal column must be coupled with restoration of spinal column stability and minimization of n...
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Ewing's / peripheral primitive neuroectodermal tumor (pPNET) of the cavernous sinus are extremely uncommon. We present clinical, radiological, pathological findings of Ewing's / pPNET involving the cavernous sinus in an eleven-month-old infant presenting with proptosis and 6th nerve palsy. MRI Contrast scans showed a well-defined, homogenously enhancing mass involving the right ...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2006
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-06-0609